Thiourea-catalyzed enantioselective iso-Pictet-Spengler reactions.
نویسندگان
چکیده
A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-γ-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system. Purification of the N-Boc-protected products by trituration or crystallization provides the optically pure tetrahydro-γ-carboline derivatives in a scalable and highly practical procedure.
منابع مشابه
Weak Brønsted acid-thiourea co-catalysis: enantioselective, catalytic protio-Pictet-Spengler reactions.
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ورودعنوان ژورنال:
- Organic letters
دوره 13 20 شماره
صفحات -
تاریخ انتشار 2011